Manuskripte Hier ist eine Liste von Publikationen unserer Wissenschaftler: 2010
Naumann JM, Messinger J, Bureik M.
Human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe. J Biotechnol. 2010 Aug 19.
Neunzig I, Dragan CA, Widjaja M, Schwaninger AE, Peters FT, Maurer HH, Bureik M.
Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.Biochim Biophys Acta. 2010 Jul 13.
Andy Zöllner, Daniela Buchheit, Markus R Meyer, Hans H Maurer, Frank T Peters & Matthias Bureik
Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes. Bioanalysis, July 2010, Vol. 2, No. 7, Pages 1277-1290
Naumann JM, Küttner G, Bureik M.
Expression and Secretion of a CB4-1 scFv-GFP Fusion Protein by Fission Yeast. Appl Biochem Biotechnol. 2010 Jul 10.
Zehentgruber D, Dragan CA, Bureik M, Lütz S.
Challenges of steroid biotransformation with human cytochrome P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces pombe. J Biotechnol. 2010 Feb 1.
Dragan CA, Buchheit D, Bischoff D, Ebner T, Bureik M.
Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast S. pombe. Drug Metab Dispos.
2009
Zöllner A, Parr MK, Dragan CA, Dräs S, Schlörer N, Peters FT, Maurer HH, Schänzer W, Bureik M.
CYP21-catalyzed production of the long term urinary metandienone metabolite 17beta-hydroxymethyl-17alpha-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping. Biol Chem. 2009 Nov 17.
Frank T Peters, Matthias Bureik and Hans H Maurer
Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast. Bioanalysis. 2009, Vol. 1 (No. 4), Pages 821-830
Goñi G, Zöllner A, Lisurek M, Velázquez-Campoy A, Pinto S, Gómez-Moreno C, Hannemann F, Bernhardt R, Medina M.
Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368.
Biochim Biophys Acta. 2009 Jul 24.
Hannemann F, Guyot A, Zöllner A, Müller JJ, Heinemann U, Bernhardt R.
The dipole moment of the electron carrier adrenodoxin is not critical for redox partner interaction and electron transfer. J Inorg Biochem. 2009 Jul;103(7):997-1004. Epub 2009 May 3. Peters FT, Dragan CA, Kauffels A, Schwaninger AE, Zapp J, Bureik M, Maurer HH.
Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis. J Anal Toxicol. 2009 May;33(4):190-7.
Peters FT, Dragan CA, Schwaninger AE, Sauer C, Zapp J, Bureik M, Maurer HH.
Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine.
Forensic Sci Int. 2009 Jan 30;184(1-3):69-73. Epub 2009 Jan 9.
Zöllner A, Dragan CA, Pistorius D, Müller R, Bode HB, Peters FT, Maurer HH, Bureik M.
Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.
Biol Chem. 2008 Dec 17.
2008
Zöllner S, Hwang KH, Wilzewski B, Carapito C, Leize-Wagner E, Van Dorsselaer A, Bernhardt R.
Aldosterone: From biosynthesis to non-genomic action onto the proteome. Steroids. 2008 Jan 6 [Epub ahead of print]
Zöllner A, Kagawa N, Waterman MR, Nonaka Y, Takio K, Shiro Y, Hannemann F, Bernhardt R
Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. FEBS J. 2008 Feb;275(4):799-810. Epub 2008 Jan 22.
Hakki, T., S. Zearo, C.A. Dragan, M. Bureik & R. Bernhardt
Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe. J Biotechnol, Feb 1;133(3):351-9.
2007
Peters, F.T., C.A Dragan, D.R. Wilde, M.R. Meyer, J. Zapp, M. Bureik & H.H. Maurer
Biotechnological Synthesis of Drug Metabolites Using Human Cytochrome P450 2D6 Heterologously Expressed in Fission Yeast Exemplified for the Designer Drug Metabolite 4'-Hydroxymethyl-alpha-Pyrrolidinobutyrophenone. Biochem Pharmacol, 74, 511-520. Derouet-Hümbert, E., C.-A. Dragan, T. Hakki & M. Bureik
Mitochondrial ROS production by adrenodoxin does not cause apoptosis in fission yeast. Apoptosis, Dec; 12(12):2135-42.
A. Zöllner, M. Pasquinelli, D. Beratan, R. Bernhardt
Experimental and theoretical analysis of the protein-protein interaction between CK2 phosphorylated Adx and its redox partner CYP11A1. JACS 2007: 129, 4206 – 4216.
2006
Dragan, C.-A., L.M. Blank & M. Bureik
Cytochrome P450-dependent biotransformation leads to increased TCA cycle activity and reduced oxygen consumption in fission yeast. Yeast 23, 779-794. Dragan, C.-A., R. W. Hartmann & M. Bureik.
A fission yeast based test system for the determination of IC50 values of anti prostate tumor drugs acting on CYP21. J Enzyme Inhib Med Chem 21, 547-556.
S. Bauer, N. Adrian, S. Kleber, B. Keil, A. Wadle, N. Fadle, A. Zöllner, R. Bernhardt, L. J. Old, M. Pfreundschuh, and C. Renner
Structure activity of Profiles of Antibody Derived TNF Fusion Proteins. J Immunology 2006: 177, 2423 – 243. A. Dhariwal, V. Mavrov and I. Schroeder
Production of lactobionic acid with process integrated electrochemical enzyme regeneration and optimisation of process variables using response surface methods (RSM) , J. Mol. Catal. B: Enzym. 42, 64-69.
2005
Bureik, M., A. Zöllner, N. Schuster, M. Montenarh & R. Bernhardt
Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1). Biochemistry 44, 3821-3830 . Ulmschneider, S., U. Müller-Vieira, M. Mitrenga, R.W. Hartmann, S. Oberwinkler-Marchais, C.D. Klein, M. Bureik, R. Bernhardt, I. Antes & T. Lengauer
Synthesis and Evaluation of Imidazolylmethylene-tetrahydronaphthalenes and -indanes: Potent Inhibitors of Aldosterone Synthase (CYP11B2). J Med Chem 48, 1796-1805 . Dragan, C.-A., S. Zearo, F. Hannemann, R. Bernhardt & M. Bureik
Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe. FEMS Yeast Res 5, 621-625 . Bureik, M., N. Brück, K. Hübel & R. Bernhardt
The human mineralocorticoid receptor (MR) only partially differentiates between different ligands after expression in fission yeast. FEMS Yeast Res 5, 627-633. Derouet-Hümbert, E., K. Römer & M. Bureik
Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria. Biol Chem 386, 453-461. Diesel, B., J. Radermacher, M. Bureik, R. Bernhardt, M. Seifert, J. Reichrath, U. Fischer & E. Meese
Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res 11, 5370-80. Bureik, M., A. Mion, C.J. Kenyon & R. Bernhardt
Inhibition of aldosterone biosynthesis by staurosporine. Biol Chem 386, 663-669. Appel, D., R.D. Schmid, C.A. Dragan, M. Bureik & V.B. Urlacher
A fluorimetric assay for cortisol. Anal Bioanal Chem 383, 182-6.
2004
Bureik, M., K. Hübel, C.-A. Dragan, J. Scher, H. Becker, N. Lenz & R. Bernhardt
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension. Mol Cell Endocrinol 217, 249-254. Bichet, A., M. Bureik, N. Lenz & R. Bernhardt
The ’Bringer’ – a very fast and highly efficient strategy for the construction of mutant libraries by error prone PCR of ring-closed plasmids. Appl Biochem Biotech 117, 115-122 . Schiffler, B., M. Bureik, W. Reinle, E.C. Müller, F. Hannemann & R. Bernhardt
The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria. J Inorg Biochem 98, 1229-1237.
A. Zöllner, I. Nogués, A. Heinz, M. Medina, C. Gómez-Moreno und R. Bernhardt
Analysis of the interaction of a hybrid system consisting of bovine adrenodoxin reductase and flavodoxin from the cyanobacterium Anabaena PCC 7119. Bioelectrochemistry 2004: 63, 61 – 65 .
B. Schiffler, A. Zöllner, R. Bernhardt
Stripping down the mitochondrial cholesterol hydroxylase system - A kinetics study. J Biological Chemistry 2004: 279, 34269 – 34276. 2002
Bureik, M., B. Schiffler, Y. Hiraoka, F. Vogel & R. Bernhardt
Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry 41, 2311-2 1. Ehmer, P.B., M. Bureik, R. Bernhardt, U. Muller & R.W. Hartmann
Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells. J Steroid Biochem Mol Biol 81, 173-9 . Bureik, M., M. Lisurek & R. Bernhardt
The human steroid hydroxylases CYP11B1 and CYP11B2. Biol Chem 383, 1537-51. Review Bureik, M., A. Zeeh & R. Bernhardt
Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. Endocr Res 28, 351-355 . A. Zöllner, F. Hannemann, M. Lisurek und R. Bernhardt
Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450scc (CYP11A1). J Inorg Biochem, 644 – 654 . 2000
Bureik, M., N. Rief, R. Drescher, A. Jungbluth, M. Montenarh & P. Wagner
An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. Int J Oncol 17, 1251-8. 1997
Bureik, M., A. Jungbluth, R. Drescher & P. Wagner
Human p53 restores DNA synthesis control in fission yeast. Biol Chem 378, 1361-71. Nickels, A., M. Bureik, M. Montenarh, M. Pfreundschuh & B. Koch
p53 antibodies: call for quality. Int J Cancer 73, 613-4.
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